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Vaginal Estradiol and Protection Against Serious Infections

Vaginal estradiol therapy is often recommended to help prevent frequent urinary tract infections. Recent research in the Journal of Urology suggests its protection goes further — it may also reduce the likelihood of serious illness when those infections do occur in older women.

Researchers reviewed the health records of more than 2 million women with repeated UTIs. Compared with women who did not use vaginal estradiol, those over age 55 who did had:

  • 51% reduced rate of serious bloodstream infection (sepsis)
  • 73% lower risk of death
  • 22% fewer hospitalizations

These benefits were not seen in premenopausal women. That may mean vaginal estradiol therapy plays a key role in protecting urinary and immune health after menopause.

What this study can and can’t tell us

The study looked at existing health records rather than testing in a controlled trial. More research is needed to confirm exactly how vaginal estradiol lowers infection risk, to determine who benefits most, and to explore long-term safety.

If you are past menopause and have UTIs more than a few times a year, it may be worth talking with a healthcare professional about vaginal estradiol therapy.

Talk it through with us

Lori and Tracy can help you work out whether vaginal estradiol therapy makes sense for you. Call (218) 343-2745 or book a consultation.

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